H2N2V1, Main, Exploration, bibRecord, 001B77

Influenza virus hemagglutinin and neuraminidase cytoplasmic tails control particle shape

Identifieur interne : 001B77 ( Main/Exploration ); précédent : 001B76; suivant : 001B78

Influenza virus hemagglutinin and neuraminidase cytoplasmic tails control particle shape

Auteurs : Hong Jin [États-Unis] ; George P. Leser [États-Unis] ; Jie Zhang [États-Unis] ; Robert A. Lamb [États-Unis]

Source :

The EMBO Journal [ 0261-4189 ] ; 1997-03-15.

RBID : ISTEX:865FDCEC9DBB4422CD028782FAF98CB82633F697

English descriptors

Teeft :
- Allantoic, Assay, Average diameter, Cdna, Cell biol, Colloidal gold, Control virus, Cytoplasmic, Cytoplasmic domain, Cytoplasmic domains, Cytoplasmic tail, Cytoplasmic tail deletion, Cytoplasmic tail deletion viruses, Cytoplasmic tails, Deletion, Electron microscope, Embryonated, Embryonated chicken eggs, Embryonated eggs, Genetic background, Glycoprotein, Gold particles, Grid, Hemagglutinin, Immunoblotting, Immunoelectron microscopy, Infectious diseases, Infectivity, Integral membrane proteins, Irregular shapes, Lamentous, Lower infectivity, Lower panel, Matrix, Matrix protein, Mdck, Mdck cells, Membrane association, Morphology, Mutation, Natl acad, Neuraminidase, Neuraminidase activity, Nucleotide sequence, Palese, Phosphotungstic acid, Polypeptide, Protein cytoplasmic tail, Reassortant, Reassortant viruses, Small plaques, Spherical particles, Spike, Sucrose, Sucrose density gradients, Tissue culture, Transfectant, Transfectant virus, Transmembrane, Transmembrane domain, Viral, Viral protein, Virion, Virol, Virology, Virus, Virus assembly, Virus envelope, Virus hemagglutinin, Virus morphology, Virus transfectant.

Abstract

The cytoplasmic tails of the influenza virus glycoproteins hemagglutinin (HA) and neuraminidase (NA) are highly conserved in sequence for all virus subtypes and it is believed that assembly of this enveloped virus depends on interactions of these domains with cytoplasmic viral components. However, it is possible to rescue altered influenza viruses lacking either the HA or NA cytoplasmic tails. We have obtained an influenza virus that lacks both the cytoplasmic tail of HA and NA. Particle production is reduced ∼10‐fold but these particles, although having a fairly normal protein composition, are greatly elongated and of extended irregular shape. We propose a model in which the interactions of the cytoplasmic tails of HA and NA with an internal viral component are so important for spherical virion shape that there is dual redundancy in the interactions.

Url:

DOI: 10.1093/emboj/16.6.1236

Affiliations:

Le document en format XML

<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Influenza virus hemagglutinin and neuraminidase cytoplasmic tails control particle shape</title>
<author><name sortKey="Jin, Hong" sort="Jin, Hong" uniqKey="Jin H" first="Hong" last="Jin">Hong Jin</name>
</author>
<author><name sortKey="Leser, George P" sort="Leser, George P" uniqKey="Leser G" first="George P." last="Leser">George P. Leser</name>
</author>
<author><name sortKey="Zhang, Jie" sort="Zhang, Jie" uniqKey="Zhang J" first="Jie" last="Zhang">Jie Zhang</name>
</author>
<author><name sortKey="Lamb, Robert A" sort="Lamb, Robert A" uniqKey="Lamb R" first="Robert A." last="Lamb">Robert A. Lamb</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:865FDCEC9DBB4422CD028782FAF98CB82633F697</idno>
<date when="1997" year="1997">1997</date>
<idno type="doi">10.1093/emboj/16.6.1236</idno>
<idno type="url">https://api.istex.fr/ark:/67375/WNG-N1QPLF7S-H/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000C51</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000C51</idno>
<idno type="wicri:Area/Istex/Curation">000C51</idno>
<idno type="wicri:Area/Istex/Checkpoint">000963</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000963</idno>
<idno type="wicri:doubleKey">0261-4189:1997:Jin H:influenza:virus:hemagglutinin</idno>
<idno type="wicri:source">PMC</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1169722</idno>
<idno type="RBID">PMC:1169722</idno>
<idno type="wicri:Area/Pmc/Corpus">000303</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000303</idno>
<idno type="wicri:Area/Pmc/Curation">000303</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000303</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000C94</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000C94</idno>
<idno type="wicri:Area/Ncbi/Merge">001344</idno>
<idno type="wicri:Area/Ncbi/Curation">001344</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001344</idno>
<idno type="wicri:doubleKey">0261-4189:1997:Jin H:influenza:virus:hemagglutinin</idno>
<idno type="wicri:Area/Main/Merge">001C39</idno>
<idno type="wicri:Area/Main/Curation">001B77</idno>
<idno type="wicri:Area/Main/Exploration">001B77</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main">Influenza virus hemagglutinin and neuraminidase cytoplasmic tails control particle shape</title>
<author><name sortKey="Jin, Hong" sort="Jin, Hong" uniqKey="Jin H" first="Hong" last="Jin">Hong Jin</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Howard Hughes Medical Institute, Northwestern University, 60208‐3500, Evanston, IL</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, IL, 60208‐3500, Evanston</wicri:regionArea>
<wicri:noRegion>Evanston</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Leser, George P" sort="Leser, George P" uniqKey="Leser G" first="George P." last="Leser">George P. Leser</name>
<affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, IL, 60208‐3500, Evanston</wicri:regionArea>
<wicri:noRegion>Evanston</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhang, Jie" sort="Zhang, Jie" uniqKey="Zhang J" first="Jie" last="Zhang">Jie Zhang</name>
<affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, IL, 60208‐3500, Evanston</wicri:regionArea>
<wicri:noRegion>Evanston</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lamb, Robert A" sort="Lamb, Robert A" uniqKey="Lamb R" first="Robert A." last="Lamb">Robert A. Lamb</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Howard Hughes Medical Institute, Northwestern University, 60208‐3500, Evanston, IL</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, IL, 60208‐3500, Evanston</wicri:regionArea>
<wicri:noRegion>Evanston</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j" type="main">The EMBO Journal</title>
<title level="j" type="alt">THE EMBO JOURNAL</title>
<idno type="ISSN">0261-4189</idno>
<idno type="eISSN">1460-2075</idno>
<imprint><biblScope unit="vol">16</biblScope>
<biblScope unit="issue">6</biblScope>
<biblScope unit="page" from="1236">1236</biblScope>
<biblScope unit="page" to="1247">1247</biblScope>
<biblScope unit="page-count">12</biblScope>
<publisher>John Wiley & Sons, Ltd</publisher>
<pubPlace>Chichester, UK</pubPlace>
<date type="published" when="1997-03-15">1997-03-15</date>
</imprint>
<idno type="ISSN">0261-4189</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0261-4189</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Allantoic</term>
<term>Assay</term>
<term>Average diameter</term>
<term>Cdna</term>
<term>Cell biol</term>
<term>Colloidal gold</term>
<term>Control virus</term>
<term>Cytoplasmic</term>
<term>Cytoplasmic domain</term>
<term>Cytoplasmic domains</term>
<term>Cytoplasmic tail</term>
<term>Cytoplasmic tail deletion</term>
<term>Cytoplasmic tail deletion viruses</term>
<term>Cytoplasmic tails</term>
<term>Deletion</term>
<term>Electron microscope</term>
<term>Embryonated</term>
<term>Embryonated chicken eggs</term>
<term>Embryonated eggs</term>
<term>Genetic background</term>
<term>Glycoprotein</term>
<term>Gold particles</term>
<term>Grid</term>
<term>Hemagglutinin</term>
<term>Immunoblotting</term>
<term>Immunoelectron microscopy</term>
<term>Infectious diseases</term>
<term>Infectivity</term>
<term>Integral membrane proteins</term>
<term>Irregular shapes</term>
<term>Lamentous</term>
<term>Lower infectivity</term>
<term>Lower panel</term>
<term>Matrix</term>
<term>Matrix protein</term>
<term>Mdck</term>
<term>Mdck cells</term>
<term>Membrane association</term>
<term>Morphology</term>
<term>Mutation</term>
<term>Natl acad</term>
<term>Neuraminidase</term>
<term>Neuraminidase activity</term>
<term>Nucleotide sequence</term>
<term>Palese</term>
<term>Phosphotungstic acid</term>
<term>Polypeptide</term>
<term>Protein cytoplasmic tail</term>
<term>Reassortant</term>
<term>Reassortant viruses</term>
<term>Small plaques</term>
<term>Spherical particles</term>
<term>Spike</term>
<term>Sucrose</term>
<term>Sucrose density gradients</term>
<term>Tissue culture</term>
<term>Transfectant</term>
<term>Transfectant virus</term>
<term>Transmembrane</term>
<term>Transmembrane domain</term>
<term>Viral</term>
<term>Viral protein</term>
<term>Virion</term>
<term>Virol</term>
<term>Virology</term>
<term>Virus</term>
<term>Virus assembly</term>
<term>Virus envelope</term>
<term>Virus hemagglutinin</term>
<term>Virus morphology</term>
<term>Virus transfectant</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract">The cytoplasmic tails of the influenza virus glycoproteins hemagglutinin (HA) and neuraminidase (NA) are highly conserved in sequence for all virus subtypes and it is believed that assembly of this enveloped virus depends on interactions of these domains with cytoplasmic viral components. However, it is possible to rescue altered influenza viruses lacking either the HA or NA cytoplasmic tails. We have obtained an influenza virus that lacks both the cytoplasmic tail of HA and NA. Particle production is reduced ∼10‐fold but these particles, although having a fairly normal protein composition, are greatly elongated and of extended irregular shape. We propose a model in which the interactions of the cytoplasmic tails of HA and NA with an internal viral component are so important for spherical virion shape that there is dual redundancy in the interactions.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Illinois</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Illinois"><name sortKey="Jin, Hong" sort="Jin, Hong" uniqKey="Jin H" first="Hong" last="Jin">Hong Jin</name>
</region>
<name sortKey="Jin, Hong" sort="Jin, Hong" uniqKey="Jin H" first="Hong" last="Jin">Hong Jin</name>
<name sortKey="Lamb, Robert A" sort="Lamb, Robert A" uniqKey="Lamb R" first="Robert A." last="Lamb">Robert A. Lamb</name>
<name sortKey="Lamb, Robert A" sort="Lamb, Robert A" uniqKey="Lamb R" first="Robert A." last="Lamb">Robert A. Lamb</name>
<name sortKey="Leser, George P" sort="Leser, George P" uniqKey="Leser G" first="George P." last="Leser">George P. Leser</name>
<name sortKey="Zhang, Jie" sort="Zhang, Jie" uniqKey="Zhang J" first="Jie" last="Zhang">Jie Zhang</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001B77 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001B77 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    H2N2V1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     ISTEX:865FDCEC9DBB4422CD028782FAF98CB82633F697
   |texte=   Influenza virus hemagglutinin and neuraminidase cytoplasmic tails control particle shape
}}

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 14 19:59:40 2020. Site generation: Thu Mar 25 15:38:26 2021

Serveur d'exploration H2N2

Influenza virus hemagglutinin and neuraminidase cytoplasmic tails control particle shape

Influenza virus hemagglutinin and neuraminidase cytoplasmic tails control particle shape

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Serveur d'exploration H2N2
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.